Said author Paolo Sassone-Corsi, Donald Bren Professor of Biological Chemistry at UCI’s School of Medicine. “Skeletal muscle, for instance, appears to be twice as responsive to fasting as the liver.” “We found fasting influences the circadian clock and fasting-driven cellular responses, which together work to attain fasting-specific temporal gene rule.”

The circadian clock performs within the body and its organs as intrinsic time-keeping machinery to preserve homeostasis in reply to the changing surrounding. And, while food is known to effect clocks in peripheral tissues, it was unclear, how the absence of food influences clock function and ultimately affects the body.

The research was guided using mice, which were subjected to 24-hour periods of fasting. While fasting, researchers noted the mice revealed a reduction in oxygen consumption (VO2), respiratory exchange ratio (RER), and energy expenditure, all of which were entirely abolished by refeeding, which equivalent results detect in humans.

“The reorganization of gene rules by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene declaration. Fasting can reprogram a change of cellular responses essentially. Also, optimal fasting in a timed manner would be the method to positively affect the cellular role and eventually benefiting health and protecting against maturing-associated diseases.”

This study opens new lines of investigation that could eventually lead to the building of nutritional strategies to improve health in humans.

Sassone-Corsi first showed the circadian rhythm-metabolism connect many 10yrs ago, specifying the metabolic pathways through which circadian proteins sense energy stages in cells.


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